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Gene Information
Gene symbol: TLR3
Gene name: toll-like receptor 3
HGNC ID: 11849
Synonyms: CD283
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNB1 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IRF3 | 1 hits |
| 4 | NFKB1 | 1 hits |
| 5 | TICAM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16027122 | Moreover, dsRNA induces TLR3 mRNA expression and activates NF-kappaB and the IFN-beta promoter in a TRIF-dependent manner. dsRNA also induces an early (1 h) and sustained increase in IFN-beta mRNA expression, and blocking IFN-beta with a specific antibody partially prevents PIC plus IFN-gamma-induced beta-cell death. |
| 2 | 16027122 | On the other hand, dsRNA plus IFN-gamma does not induce apoptosis in INS-1E cells, and expression of TLR3 and type I IFNs mRNAs is not detected in these cells. |
| 3 | 18223009 | TLR3 signaling mediated PICex-induced nuclear factor-kappaB (NF-kappaB) and IRF-3 activation and beta-cell apoptosis. |
| 4 | 18223009 | PICin activated NF-kappaB and IRF-3 in a TLR3-independent manner, induced eukaryotic initiation factor 2 alpha phosphorylation, and triggered a massive production of interferon (IFN)-beta. |