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Gene Information
Gene symbol: TMEM119
Gene name: transmembrane protein 119
HGNC ID: 27884
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALPI | 1 hits |
| 2 | BGLAP | 1 hits |
| 3 | BMP2 | 1 hits |
| 4 | PTH | 1 hits |
| 5 | SDCBP2 | 1 hits |
| 6 | SMAD1 | 1 hits |
| 7 | SMAD3 | 1 hits |
| 8 | SMAD5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21239498 | The levels of Tmem119 increased with time in cultures of MC3T3-E1 cells and mouse mesenchymal ST-2 cells committed to the osteoblast lineage by BMP-2. |
| 2 | 21239498 | PTH stimulated Tmem119 levels within 1 h as determined by Western blot analysis and immunocytochemistry in MC3T3-E1 cells. |
| 3 | 21239498 | MC3T3-E1 cells stably overexpressing Tmem119 exhibited elevated levels of Runx2, osteocalcin, alkaline phosphatase, and ?-catenin, whereas Tmem119 augmented BMP-2-induced Runx2 levels in mesenchymal cells. |
| 4 | 21239498 | Tmem119 interacted with Runx2, Smad1, and Smad5 in C2C12 cells. |
| 5 | 21239498 | In conclusion, we identified a Smad3-related factor, Tmem119, that is induced by PTH and promotes differentiation in mouse osteoblastic cells. |
| 6 | 21239498 | Tmem119 is an important molecule in the pathway downstream of PTH and Smad3 signaling in osteoblasts. |