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Gene Information

Gene symbol: TMPRSS11D

Gene name: transmembrane protease, serine 11D

HGNC ID: 24059

Related Genes

# Gene Symbol Number of hits
1 EP300 1 hits
2 MLXIPL 1 hits
3 SNF1LK2 1 hits

Related Sentences

# PMID Sentence
1 21084751 In this study, we have identified the histone acetyltransferase (HAT) coactivator p300 and serine/threonine kinase salt-inducible kinase 2 (SIK2) as key upstream regulators of ChREBP activity.
2 21084751 SIK2 inhibited p300 HAT activity by direct phosphorylation on Ser89, which in turn decreased ChREBP-mediated lipogenesis in hepatocytes and mice overexpressing SIK2.
3 21084751 Finally, in mouse models of type 2 diabetes and obesity, low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis.
4 20655188 Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin.