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Gene Information
Gene symbol: TMPRSS11D
Gene name: transmembrane protease, serine 11D
HGNC ID: 24059
Related Genes
Related Sentences
# |
PMID |
Sentence |
1 |
21084751
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In this study, we have identified the histone acetyltransferase (HAT) coactivator p300 and serine/threonine kinase salt-inducible kinase 2 (SIK2) as key upstream regulators of ChREBP activity.
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2 |
21084751
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SIK2 inhibited p300 HAT activity by direct phosphorylation on Ser89, which in turn decreased ChREBP-mediated lipogenesis in hepatocytes and mice overexpressing SIK2.
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3 |
21084751
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Finally, in mouse models of type 2 diabetes and obesity, low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis.
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4 |
20655188
|
Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin.
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