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Gene Information
Gene symbol: TNFRSF10B
Gene name: tumor necrosis factor receptor superfamily, member 10b
HGNC ID: 11905
Synonyms: DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CFLAR | 1 hits |
| 2 | FADD | 1 hits |
| 3 | NOS2A | 1 hits |
| 4 | TNF | 1 hits |
| 5 | TNFRSF10A | 1 hits |
| 6 | TNFRSF10C | 1 hits |
| 7 | TNFRSF10D | 1 hits |
| 8 | TNFRSF25 | 1 hits |
| 9 | TNFSF10 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2648900 | An increase of A30, DR3, DR4, BfF1, C4AQ0 and C4BQ0 and decrease of B40, DR2, DR5 and DR6 were found in diabetes when compared to the value observation controls. |
| 2 | 15718275 | Immunohistochemistry displayed a greater amount of TNF-related apoptosis-inducing ligand (TRAIL) and KILLER, a key murine ligand and receptor involved in the extrinsic pathway, expressed in cumulus cells from hyperglycemic mice compared with controls, suggesting that this apoptotic pathway may be up-regulated under diabetic stress. |
| 3 | 20451496 | In the present study, TRAIL treatment in INS-1 cells upregulated DcR1 and downregulated DR5 without altering the expression of DcR2 and DR4. |
| 4 | 19432816 | Of these receptors, only DR5 was expressed consistently in glioblastoma cell lines and tumour tissues, ruling out the role of DcR1/2 in TRAIL resistance. |
| 5 | 19432816 | Upon TRAIL binding, DR5 was homotrimerized and recruited Fas-associated death domain (FADD) and caspase-8 for the assembly of death-inducing signalling complex (DISC) in the lipid rafts of the plasma membrane. |
| 6 | 19432816 | In TRAIL-resistant cells, however, DR5-mediated DISC was modified by receptor-interacting protein (RIP), cellular FADD-like interleukin-1beta-converting enzyme inhibitory protein (c-FLIP) and phosphoprotein enriched in diabetes or in astrocyte-15 (PED/PEA-15). |
| 7 | 20696468 | The immunohistochemical study revealed increased immunostaining of TRAIL and DR5 in osteoblastic cells of the diaphysis (pre-metaphysis) and epiphysis treated with STZ and L-NAME, related to activation of osteoblastic apoptotic death, while the group receiving L-arginine was comparable to the control group and the higher indications of iNOS activity that may reflect its induction by L-arginine administration. |