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Gene Information
Gene symbol: TNFRSF10C
Gene name: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
HGNC ID: 11906
Synonyms: DcR1, TRAILR3, LIT, TRID, CD263
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NFKB1 | 1 hits |
| 2 | TNFRSF10A | 1 hits |
| 3 | TNFRSF10B | 1 hits |
| 4 | TNFRSF10D | 1 hits |
| 5 | TNFSF10 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20451496 | Four related receptors bind TRAIL: two death receptors (DR4 and DR5) that promote apoptosis, and two decoy receptors (DcR1 and DcR2) that act as dominant-negative inhibitors of TRAIL-mediated apoptosis. |
| 2 | 20451496 | In the present study, TRAIL treatment in INS-1 cells upregulated DcR1 and downregulated DR5 without altering the expression of DcR2 and DR4. |
| 3 | 20451496 | The resistance to apoptosis in INS-1 cells might therefore, be a consequence of DcR1 upregulation and DR5 downregulation, and the transcription factor, NF-kappaB, could regulate the sensitivity of cells to TRAIL by controlling the ratio of decoy to death receptors. |