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Gene Information
Gene symbol: TNFRSF11A
Gene name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
HGNC ID: 11908
Synonyms: RANK, CD265
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IDDM2 | 1 hits |
| 2 | RUNX2 | 1 hits |
| 3 | TNFRSF11B | 1 hits |
| 4 | TNFSF11 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20818503 | Markers of bone resorption, activity of tartrate-resistant acid phosphatase (TRAP) and cathepsin K and the number of osteoclasts in the proximal tibia and urinary excretion of deoxypyridinoline, were higher in diabetic rats than control rats. mRNA levels of receptor for activation of NF-kappaB (RANK), c-fos, c-jun, TRAP and cathepsin K were significantly increased in diabetic rats, although RANK ligand, osteoprotegerin, macrophage colony-stimulating factor and c-fms levels were similar to the control value. |
| 2 | 20818503 | These suggested that short-term IDDM induced upregulation of osteoclastogenesis with an increase in RANK and downregulation of osteoblastogenesis with a decrease in Runx2 in bone. |
| 3 | 21659498 | The receptor activator of nuclear factor-?B (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) signaling pathway (RANKL/RANK/OPG signaling) is implicated in the osteolysis associated with diabetic Charcot neuroarthropathy (CN); however, the links with medial arterial calcification (MAC) seen in people with CN are unclear. |