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Gene Information
Gene symbol: TPH1
Gene name: tryptophan hydroxylase 1
HGNC ID: 12008
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HTR2B | 1 hits |
| 2 | INS | 1 hits |
| 3 | LEP | 1 hits |
| 4 | SLC6A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1279445 | In addition, an alternative method was used to assess 5-HT activity in thyroidectomized (TX) rats, i.e. measurement of 5-HT disappearance after inhibition of tryptophan hydroxylase with p-chlorophenylalanine (PCPA). |
| 2 | 19859528 | We combined biochemical and electrophysiological analyses of mice selectively deficient in peripheral tryptophan hydroxylase (Tph1-/-) and 5-HT to show that intracellular 5-HT regulates insulin secretion. |
| 3 | 21320265 | Adipocytes were isolated from normal rat visceral abdominal adipose tissue and analysed for the expression of serotonin receptors, the serotonin transporter (5HTT/SERT), activation of serotonin synthesis (tryptophan hydroxylase 1, Tph1) and secretion and serotonin-induced leptin regulation by RT-PCR and protein analyses. |
| 4 | 21320265 | In vitro experiments showed that adipocytes express serotonin receptors, Tph1 and 5HTT, synthesize and secrete serotonin and that serotonin regulates leptin in mature adipocytes. |