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Gene Information
Gene symbol: TPR
Gene name: translocated promoter region, nuclear basket protein
HGNC ID: 12017
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAT | 1 hits |
| 2 | HSP90AA1 | 1 hits |
| 3 | PRKAA2 | 1 hits |
| 4 | SOD1 | 1 hits |
| 5 | STK11 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19506739 | Consistent with this model, Hsp90 has recently been shown to be a chaperone for Tah1p (TPR-containing protein associated with Hsp90) and Pih1p (protein interacting with Hsp90), which connect to the chromatin remodelling factor Rvb1p (RuvB-like protein 1)/Rvb2p in yeast [1]. |
| 2 | 18063812 | Exposure of cultured VSMCs to either TPr agonists, IBOP and U46619, or exogenous hydrogen peroxide (H2O2) caused time- and dose-dependent AMPK activation, as evidenced by increased phosphorylation of both AMPK-Thr172 and acetyl-coenzyme A carboxylase-Ser79, a downstream enzyme of AMPK, whereas SQ29548, a selective TPr antagonist, significantly attenuated TPr-enhanced AMPK activation. |
| 3 | 18063812 | Furthermore, adenoviral overexpression of catalase (an H2O2 scavenger) abolished, whereas superoxide dismutase (which catalyzes H2O2 formation) enhanced, IBOP-induced AMPK activation, suggesting that TPr-activated AMPK was mediated by H2O2. |
| 4 | 18063812 | In addition, direct mutagenesis of either Ser428 or Ser307 of LKB1 into alanine, like the kinase-dead LKB1 mutant, abolished both TPr-stimulated AMPK activation and coimmunoprecipitation. |