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Gene Information
Gene symbol: TRAF6
Gene name: TNF receptor-associated factor 6, E3 ubiquitin protein ligase
HGNC ID: 12036
Synonyms: RNF85
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL1B | 1 hits |
| 2 | MAP3K7 | 1 hits |
| 3 | MIRN146A | 1 hits |
| 4 | SOCS3 | 1 hits |
| 5 | TNFAIP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21249428 | Among the target genes of miR-146a, TRAF-6 mRNA expression was significantly increased in patients with Type 2 diabetes while there was no significant difference in the mRNA levels of IRAK1 in the study groups. |
| 2 | 21249428 | While SOCS-3 mRNA levels increased, plasma TNF? and IL-6 levels were also significantly higher in patients with type 2 diabetes. miR-146a expression was negatively correlated to glycated hemoglobin, insulin resistance, TRAF6, and NF?B mRNA levels and circulatory levels of TNF? and IL-6. |
| 3 | 16543409 | By coimmunoprecipitation, it was shown that SOCS-3 inhibited the association between TRAF6 and TAK1 and that SOCS-3 coimmunoprecipitated with TAK1 and TRAF6. |
| 4 | 16543409 | Because ubiquitination of TRAF6 is required for activation of TAK1, we analyzed the role of SOCS-3 on TRAF6 ubiquitination and found that SOCS-3 inhibited ubiquitin modification of TRAF6. |
| 5 | 16543409 | These results indicate that SOCS-3 inhibits IL-1 signal transduction by inhibiting ubiquitination of TRAF6, thus preventing association and activation of TAK1. |
| 6 | 16936197 | Activation of NF-kappaB by TNF receptor-associated factor (TRAF) 2, TRAF6, NF-kappaB-inducing kinase, or protein kinase D, which transduce signals downstream of Toll-like receptors, TNF receptors, and free radicals, respectively, were all potent activators of the A20 promoter. |