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Gene Information

Gene symbol: TRPC6

Gene name: transient receptor potential cation channel, subfamily C, member 6

HGNC ID: 12338

Synonyms: TRP6

Related Genes

#	Gene Symbol	Number of hits
1	AGT	1 hits
2	CAT	1 hits
3	F2	1 hits
4	PRKCA	1 hits
5	STIM1	1 hits
6	TRPC1	1 hits
7	TRPC3	1 hits

Related Sentences

#	PMID	Sentence
1	17699555	In cultured human MCs, high glucose significantly reduced expression of TRPC6 protein, but there was no effect on either TRPC1 or TRPC3.
2	17699555	Patch-clamp experiments showed that ANG II-stimulated membrane currents in MCs were significantly attenuated or enhanced by knockdown or overexpression of TRPC6, respectively.
3	17699555	Fura-2 fluorescence measurements revealed that the ANG II-induced Ca(2+) influxes were markedly inhibited in MCs with TRPC6 knockdown, reminiscent of the impaired Ca(2+) entry in response to ANG II in high glucose-treated MCs.
4	21303733	Treatment with TG or the agonist thrombin enhanced co-immunoprecipitation of STIM1 with Orai1, hTRPC1 and hTRPC6 in platelets from healthy donors, a response that was significantly reduced in platelets from diabetic patients.
5	21303733	Our results indicate that store-operated divalent cation entry is reduced in platelets from type 2 diabetic subjects, which is likely mediated by impairment of the association of STIM1 with the channel subunits Orai1, hTRPC1 and hTRPC6 and might be involved in the pathogenesis of the altered platelet responsiveness observed in diabetic patients.
6	21525431	The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation.
7	21525431	Catalase as well as superoxide dismutase were able to prevent the inhibitory effect of HG on TRPC6.