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Gene Information
Gene symbol: TSC2
Gene name: tuberous sclerosis 2
HGNC ID: 12363
Synonyms: tuberin, LAM
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | BCL2 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | CD36 | 1 hits |
| 5 | CRTC1 | 1 hits |
| 6 | CYCS | 1 hits |
| 7 | INS | 1 hits |
| 8 | OGG1 | 1 hits |
| 9 | PARP1 | 1 hits |
| 10 | PNPLA2 | 1 hits |
| 11 | TSC1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18599524 | Inhibition of phosphatidylinositol 3-kinase/Akt significantly reduced high glucose-induced tuberin phosphorylation and restored OGG1 expression. |
| 2 | 18599524 | Hyperglycemia in type 1 diabetes and treatment of proximal tubular epithelial cells with high glucose leads to phosphorylation/inactivation of tuberin and downregulation of OGG1 via a redox-dependent activation of Akt in renal tubular epithelial cells. |
| 3 | 19286253 | The genes TSC1 and TSC2, encoding hamartin and tuberin, respectively, have been shown to be involved in the development of the autosomal dominantly inherited tumor syndrome tuberous sclerosis (TSC). |
| 4 | 18926585 | Tuberous sclerosis complex (TSC) gene products, TSC1 and TSC2 are tumor suppressors and specifically suppress TORC1 activity. |
| 5 | 18926585 | Mutation of either TSC1 or TSC2 causes TSC disease, which is characterized by formation of hamartomas in multiple organs. |
| 6 | 20068142 | Overexpression of ATGL in these cells antagonized the lipogenic effect of TSC2 knockout. |
| 7 | 21289215 | Induction of diabetes also increased phosphorylation of tuberin in association with mTOR activation (measured by p70S6K phosphorylation), inactivation of Bcl-2, increased cytosolic cytochrome c expression, activation of caspase 3, and cleavage of PARP; insulin treatment prevented these changes. |
| 8 | 21289215 | In vitro, exposure of PTE cells to HG increased phosphorylation of tuberin and p70S6K, phosphorylation of Bcl-2, expression of cytosolic cytochrome c, and caspase 3 activity. |
| 9 | 21886784 | We previously found that chronic tuberous sclerosis protein 2 (TSC2) deletion induces activation of mammalian target of rapamycin Complex 1 (mTORC1) and leads to hypertrophy of pancreatic beta cells from pancreatic beta cell-specific TSC2 knockout (?TSC2(-/-)) mice. |
| 10 | 21886784 | Activation of mTORC1 by TSC2 ablation increases mitochondrial biogenesis and enhances insulin secretion from pancreatic beta cells. |
| 11 | 21871459 | The myocardium of untreated db/db-/- mice exhibited a marked increase of the phosphorylation of AMPK, ACC, TSC2, expression of p53 and fatty acid translocase (FAT/CD36) membrane expression. |