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Gene Information

Gene symbol: TSPYL2

Gene name: TSPY-like 2

HGNC ID: 24358

Synonyms: SE20-4, HRIHFB2216, CTCL, DENTT, CDA1, CINAP

Related Genes

#	Gene Symbol	Number of hits
1	APOE	1 hits
2	COL1A1	1 hits
3	CTGF	1 hits
4	HK2	1 hits
5	SMAD3	1 hits
6	TGFB1	1 hits
7	TGFBR1	1 hits

Related Sentences

#	PMID	Sentence
1	19847393	We explored how a recently identified molecule, cell division autoantigen 1 (CDA1), influences the profibrotic TGF-beta pathway leading to vascular ECM accumulation.
2	19847393	In vivo studies indicated that the mRNA levels of CDA1-encoding gene Tspyl2 and protein levels of CDA1 were elevated in the aorta of diabetic Apoe(-/-) mice, accompanied by increased levels of Tgf-beta (also known as Tgfb1), Ctgf and ECM accumulation.
3	19847393	Knockdown of CDA1-encoding gene Tspyl2 to reduce cellular CDA1 level markedly attenuated TGF-beta-stimulated MAD homologue 3 (drosophila; SMAD3) phosphorylation and transcriptional activities.
4	19847393	CDA1 overproduction increased and Tspyl2 knockdown decreased expression of TGF-beta receptor type I, TbetarI (also known as Tgfbr1), but not TGF-beta receptor type II, TbetarII (also known as Tgfbr2), providing a mechanism for CDA1's action in modulating TGF-beta signalling.
5	19847393	Knockdown of CDA1-encoding gene Tspyl2 also blocked the profibrotic effect of TGF-beta in VSMCs.
6	19847393	CDA1 is therefore a potential target for attenuating vascular ECM accumulation caused by enhanced TGF-beta action, as seen in diabetic atherosclerosis.
7	20962744	CDA1 small interfering RNA knockdown markedly attenuated, whereas its overexpression increased TGF-? signaling, modulating the expression of TGF-?, TGF-? receptors, connective tissue growth factor, collagen types I, III, IV, and fibronectin genes in HK-2 cells.
8	20962744	CDA1 knockdown effectively blocked TGF-?-stimulated expression of collagen genes.