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Gene Information
Gene symbol: TXN
Gene name: thioredoxin
HGNC ID: 12435
Synonyms: TRX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GAD2 | 1 hits |
| 2 | INS | 1 hits |
| 3 | KLRG1 | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | MAPK14 | 1 hits |
| 6 | PPARA | 1 hits |
| 7 | PRKAA1 | 1 hits |
| 8 | SOD1 | 1 hits |
| 9 | SPP1 | 1 hits |
| 10 | TIMP3 | 1 hits |
| 11 | TXNIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10814590 | However, this difficulty was recently surmounted in our laboratory by expressing GAD65 as a fusion protein with thioredoxin [Papouchado, Valdez, Ghiringhelli, Poskus and Ermácora (1997) Eur. |
| 2 | 15128745 | Diabetic animals exhibited increased vascular expression of Txnip and reduced thioredoxin activity, which normalized with insulin treatment. |
| 3 | 15128745 | These studies implicate reduced thioredoxin activity through interaction with Txnip as an important mechanism for vascular oxidative stress in diabetes mellitus. |
| 4 | 17555594 | TRX activity was assayed by the insulin disulfide reducing assay. |
| 5 | 20023662 | Here we show that NLRP3 interacted with thioredoxin (TRX)-interacting protein (TXNIP), a protein linked to insulin resistance. |
| 6 | 20023662 | Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. |
| 7 | 20828387 | In their heart PPAR gamma, tissue inhibitor of metalloproteinase-4 (TIMP-4) and anti-oxidant thioredoxin were attenuated whereas matrix metalloproteinase (MMP)-9, TIMP-3 and NADPH oxidase 4 (NOX4) were induced. |
| 8 | 20453393 | Dipyridamole decreased glucose-induced osteopontin through inhibition of phosphodiesterase, thereby increasing intracellular levels of adenosine-3',5'-cyclic monophosphate (cAMP) and guanosine-3',5'-cyclic monophosphate (cGMP), and increased thioredoxin expression to inhibit the reactive oxygen species (ROS) system. |
| 9 | 17949261 | The progression of hyperglycemia and the reduction of body weight gain and insulin content of the db/db mouse were significantly suppressed by the TRX expression. |
| 10 | 17949261 | Furthermore, TRX suppressed the reduction of Pdx-1 and MafA expression in the beta cells, which may be one of the cellular mechanisms for protecting beta cells from losing their insulin-secreting capacity. |
| 11 | 20460580 | Finally, glycation inhibitor aminoguanidine administration during MG treatment of cultured cells reduced AGE formation, increased Trx activity, restored Trx-ASK1 interaction, and reduced p38 MAPK phosphorylation and activity, caspase-3 activation, and LDH release (P < 0.01). |
| 12 | 21750018 | These results suggested that AMPK activation appeared to play a key role in upregulated expression of thioredoxin and Mn SOD, and mitigation of cellular oxidative stress and/or ER stress by wolfberry and zeaxanthin and/or lutein. |
| 13 | 21615774 | The expression of TRX and insulin in islets and plasma SOD and CAT activity were lower, but the expression of TXNIP in islets and plasma MDA were higher, in diabetic compared with normal control rats. |
| 14 | 21615774 | Upregulated expression of TRX and insulin and downregulated expression of TXNIP were observed in probucol-treated diabetic rats. |