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Gene Information
Gene symbol: TXN2
Gene name: thioredoxin 2
HGNC ID: 17772
Synonyms: MT-TRX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP3 | 1 hits |
| 2 | CYCS | 1 hits |
| 3 | MAP3K5 | 1 hits |
| 4 | TXNIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19959470 | In mitochondria, TXNIP binds to and oxidizes Trx2, thereby reducing Trx2 binding to ASK1 and allowing for ASK1 phosphorylation/activation, resulting in induction of the mitochondrial pathway of apoptosis with cytochrome c release and caspase-3 cleavage. |
| 2 | 21134355 | Compared to the high glucose group, co-treatment with 100 nM SS31 significantly protected HRECs from high glucose-induced injury, reduced the production of ROS in mitochondria, stabilized ??(m), decreased the release of cytochrome c from mitochondria to cytoplasm, decreased the expression of caspase-3 and increased the expression of Trx-2 in high glucose-treated HRECs. |
| 3 | 21134355 | SS31 attenuates the high glucose-induced injuries on HRECs by stabilizing ??(m), decreasing ROS production, preventing the release of cytochrome c from mitochondria, decreasing the expression of caspase-3 and increasing the expression of Trx-2. |