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Gene Information

Gene symbol: TXNDC4

Gene name: thioredoxin domain containing 4 (endoplasmic reticulum)

HGNC ID: 18311

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	PPARA	1 hits
3	PPARG	1 hits

Related Sentences

#	PMID	Sentence
1	18177270	Secretion of the adiponectin oligomers is tightly controlled by a pair of molecular chaperones in the ER (endoplasmic reticulum), including ERp44 (ER protein of 44 kDa) and Ero1-Lalpha (ER oxidoreductase 1-Lalpha).
2	19622782	Expression of the chaperone protein ERp44, which retains adiponectin within the cell, was decreased by TZD treatment.
3	19622782	Finally, TZDs promote the selective secretion of HMW adiponectin, potentially, in part, through decreasing the expression of the adiponectin-retaining protein ERp44.
4	20484463	Within adipocytes, adiponectin is retained in the lumen of the endoplasmic reticulum (ER) by binding to the thiol protein ER resident protein 44 kDa (ERp44), which is apparently regulated by the activation of nuclear receptor peroxisome proliferator-activated receptor (PPAR)-gamma.
5	20484463	In human embryonic kidney 293 cells stably transfected with cDNA encoding porcine adiponectin, the secretion of adiponectin was significantly up-regulated and the ERp44 mRNA was down-regulated observably, by either the treatment of PPARgamma agonist rosiglitazone or the overexpression of PPARgamma in these cells.
6	20484463	Taken together, our results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44, which in turn controls the secretion of adiponectin.