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Gene Information
Gene symbol: USF1
Gene name: upstream transcription factor 1
HGNC ID: 12593
Synonyms: UEF, MLTFI, bHLHb11
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATIC | 1 hits |
| 2 | DNMT1 | 1 hits |
| 3 | HNF4A | 1 hits |
| 4 | INS | 1 hits |
| 5 | LIPE | 1 hits |
| 6 | NEUROG3 | 1 hits |
| 7 | NRF1 | 1 hits |
| 8 | PDX1 | 1 hits |
| 9 | PRKAA1 | 1 hits |
| 10 | PRMT1 | 1 hits |
| 11 | REN | 1 hits |
| 12 | RUNX2 | 1 hits |
| 13 | TGFA | 1 hits |
| 14 | TGFB1 | 1 hits |
| 15 | ZEB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21814221 | Variants in USF1, ABCC8, ISL1 and KCNJ11 showed nominal association, while haplotypes in these genes were significantly associated. rs3812704 upstream of NEUROG3 significantly increased risk for type 2 diabetes in normal-weight/lean subjects (OR=1.68 (95%CI 1.25-2.24), P=4.9 × 10(-4)). |
| 2 | 11812735 | Moreover, HSL mRNA levels were decreased in USF1- and USF2-deficient mice. |
| 3 | 16035391 | The hepatic nuclear factor 4alpha (HNF4alpha) gene partly explains the linkage peak on chromosome 20, while the upstream transcription factor (USF1) is associated with familial combined hyperlipidaemia (FCHL) and maps close to the type 2 diabetes associated 1q peak. |
| 4 | 15479157 | We also show that, like Sp1 and E-box-binding proteins such as USF1 and USF2, NRF-1 causes DNA bending, in this case producing a bend of 57 degrees towards the major groove. |
| 5 | 15983197 | An E-box element from the murine TGF-beta1 promoter revealed USF1 and USF2 binding by EMSA. |
| 6 | 15983197 | Chromatin immunoprecipitation assay revealed in vivo binding of USF1 to a glucose-responsive region of the TGF-beta1 promoter. |
| 7 | 15983197 | Transient cotransfection studies of 293 cells with USF1 led to a twofold increase in TGF-beta1 promoter activity and a 46% increase in secreted TGF-beta1 protein levels. |
| 8 | 17846119 | USF1 interacts directly with the histone H4R3-specific methyltransferase PRMT1. |
| 9 | 21147283 | However, USF-1 and SHP were not involved in metformin-induced Runx2 expression. |
| 10 | 20388924 | In a small subgroup of obese FCHL, FABP4 levels were associated with triglyceride-rich lipoproteins independent of insulin resistance. |
| 11 | 21389977 | TGF-?1 increased the occupancy of activators USF1 and Tfe3, and decreased that of the repressor Zeb1 on the TGF-?1 promoter E-box binding sites. |
| 12 | 21543418 | The transcription factor upstream stimulatory factor 1 (USF1) is an important regulator of glucose-mediated transforming growth factor (TGF)-?1 expression in mesangial cells; however, its role in the development of diabetic kidney disease has not been evaluated. |
| 13 | 21543418 | TGF-?1 and renin gene expression and protein were substantially increased in the WT diabetic mice but not in USF1 -/- diabetic mice. |
| 14 | 21543418 | Activation of AMPK with AICAR stimulated AMPK activity and reduced nuclear accumulation of USF1. |
| 15 | 21779870 | Histone modifications, PCAF, USF1 and DNA methyltransferase (Dnmt) 1 binding were assessed by chromatin immunoprecipitation (ChIP) assays and DNA methylation was quantified by pyrosequencing. |
| 16 | 21779870 | These studies demonstrate a novel mechanism whereby a short treatment course of Ex-4 in the newborn period permanently increases HAT activity by recruiting USF1 and PCAF to the proximal promoter of Pdx1 which restores chromatin structure at the Pdx1 promoter and prevents DNA methylation, thus preserving Pdx1 transcription. |