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Gene Information
Gene symbol: USF2
Gene name: upstream transcription factor 2, c-fos interacting
HGNC ID: 12594
Synonyms: FIP, bHLHb12
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGTR1 | 1 hits |
| 2 | CREB1 | 1 hits |
| 3 | LIPE | 1 hits |
| 4 | MLXIPL | 1 hits |
| 5 | PKLR | 1 hits |
| 6 | TGFB1 | 1 hits |
| 7 | THBS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11812735 | Moreover, HSL mRNA levels were decreased in USF1- and USF2-deficient mice. |
| 2 | 15983197 | An E-box element from the murine TGF-beta1 promoter revealed USF1 and USF2 binding by EMSA. |
| 3 | 15983197 | Wild-type and USF2 knockout mice exhibited a 2.5-fold stimulation of renal TGF-beta1 expression upon fasting and refeeding with a carbohydrate-rich diet, whereas USF1 knockout mice exhibited only a minimal increase of renal TGF-beta1 upon refeeding. |
| 4 | 16891625 | Both ChREBP and SREBP-1c were required for the induction of the fatty acid synthase (FAS) promoter by glucose, and chromatin immunoprecipitation (ChIP) assay revealed that glucose induced the binding of both ChREBP and SREBP-1c to the FAS promoter without affecting USF2 binding. |
| 5 | 16891625 | By contrast, ChIP assay revealed that high glucose prompted direct binding of ChREBP, but not SREBP-1c or USF2, to the liver-type pyruvate kinase (L-PK) promoter. |
| 6 | 17881461 | Our previous studies demonstrated that the transcription factor, upstream stimulatory factor 2 (USF2), was upregulated by high glucose, which bound to an 18-bp sequence in the thrombospondin 1 (TSP1) gene promoter and regulated high glucose-induced TSP1 expression and TGF-beta activity in mesangial cells, suggesting that USF2 might play a role in the development of diabetic nephropathy. |
| 7 | 20814220 | Treatment of HK-2 cells with an angiotensin II receptor 1 (AT1) blocker--losartan--prevented high-glucose-induced USF2 expression and high-glucose-enhanced phosphorylation of CREB (cAMP response element-binding protein). |
| 8 | 20814220 | Our data established that high glucose stimulated USF2 expression in HK-2 cells, at least in part, through angiotensin II-AT1-dependent activation of CREB, which can contribute to diabetic tubulointerstitial fibrosis. |