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Gene Information
Gene symbol: UTS2
Gene name: urotensin 2
HGNC ID: 12636
Synonyms: UII, U-II, UCN2, PRO1068
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CTNNB1 | 1 hits |
| 3 | CYSLTR2 | 1 hits |
| 4 | GSK3B | 1 hits |
| 5 | INS | 1 hits |
| 6 | UTS2R | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17931747 | Urotensin II (U-II) and urotensin II-related peptide (URP) are the endogenous ligands for the orphan G-protein-coupled receptor GPR14 now renamed UT. |
| 2 | 18473773 | Vasoconstriction is not its only effect; U-II and its receptor have been demonstrated in the central nervous system, where U-II induces a cardiovascular, behavioural, motor and endocrine response and in the kidney, where it seems to influence renal hemodynamics but also salt and water excretion, in rat pancreas where it inhibits insulin secretion, in the heart where it seems to play a role in cardiac hypertrophy and fibrosis. |
| 3 | 21559414 | Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). |
| 4 | 20416349 | We therefore investigated in adult cardiomyocytes, if UII phosphorylates GSK-3beta and Akt, one of its upstream regulators and stabilizes beta-catenin, a GSK-3beta dependent nuclear transcriptional co-activator. |
| 5 | 20416349 | UII also increased phosphorylation of Akt and its downstream target GSK-3beta. beta-Catenin protein levels were increased. |
| 6 | 20416349 | The UII-induced adult cardiomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathways and is accompanied by the stabilization of the beta-catenin. |