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Gene Information
Gene symbol: VHL
Gene name: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
HGNC ID: 12687
Synonyms: VHL1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EPO | 1 hits |
| 2 | INS | 1 hits |
| 3 | SLC2A2 | 1 hits |
| 4 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21029313 | Several recent studies have shown that Vhl deletion in ?-cells results in Hif1? activation, impaired glucose-stimulated insulin secretion (GSIS) and glucose intolerance. |
| 2 | 21242957 | We generated ?-cell-specific VHL-knockout mice using the Cre-loxP recombination system driven by the rat insulin promoter to assess the role of VHL in glucose homeostasis and ?-cell function. |
| 3 | 21242957 | VHL deletion in the pancreatic ?-cells led to impaired glucose tolerance due to defects in glucose-stimulated insulin secretion and ?-cell mass with age. |
| 4 | 21242957 | VHL-knockout islets had decreased GLUT2, but increased glucose transporter 1 and vascular endothelial growth factor expression. |
| 5 | 21242957 | Given that erythropoietin (EPO) is a target gene of the HIF pathway, which is not expressed in islets, we tested whether activating EPO signaling by systemic administration with recombinant human EPO (rHuEPO) can overcome the ?-cell defects that occurred with VHL loss. |