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Gene Information
Gene symbol: ADAM17
Gene name: ADAM metallopeptidase domain 17
HGNC ID: 195
Synonyms: cSVP, CD156B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGT | 1 hits |
| 2 | EGFR | 1 hits |
| 3 | TGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19535569 | In mice, angiotensin II infusion induces renal fibrosis via ADAM17-mediated TGF-alpha shedding and subsequent EGFR activation. |
| 2 | 19535569 | In renal fibrosis, ADAM17 colocalized with TGF-alpha. |
| 3 | 19535569 | Moreover, in cultured human podocytes and proximal tubular cells, pharmacological ADAM17 inhibition reduced constitutive TGF-alpha shedding by 78% (P < 0.005) and 100% (P < 0.05), respectively, and phorbol ester-induced TGF-alpha shedding by 84% (P < 0.005) and 92% (P = 0.005), respectively. |