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Gene Information
Gene symbol: ATP6AP2
Gene name: ATPase, H+ transporting, lysosomal accessory protein 2
HGNC ID: 18305
Synonyms: M8-9, APT6M8-9, ATP6M8-9
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PTGS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21737546 | In cultured podocytes overexpressing COX-2, high glucose induced cell injury and increased both expression of the pro(renin) receptor and activation of the renin-angiotensin system. |
| 2 | 21737546 | In vivo, podocyte pro(renin) receptor expression increased in diabetic COX-2-transgenic mice, and treatment with a COX-2 inhibitor abrogated the upregulation of (pro)renin receptor and reduced albuminuria, foot-process effacement, and mesangial matrix expansion. |
| 3 | 21737546 | In summary, these results demonstrate that increased expression of podocyte COX-2 predisposes to diabetic glomerular injury and that the (pro)renin receptor may be one mediator for this increased susceptibility to injury. |