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Gene Information
Gene symbol: CBLC
Gene name: Cbl proto-oncogene, E3 ubiquitin protein ligase C
HGNC ID: 15961
Synonyms: CBL-3, CBL-SL, RNF57
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD2AP | 1 hits |
| 2 | GDNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18753381 | In contrast to their dissociation from autophosphorylated Ret, an interaction between CD2AP and Cbl-3 is induced by GDNF stimulation of sympathetic neurons, suggesting that CD2AP and Cbl-3 dissociate from Ret as a complex. |
| 2 | 18753381 | In combination with CD2AP, however, Cbl-3 promotes Ret degradation rapidly and almost completely blocks survival promotion by GDNF, suggesting that Cbl-3 acts as a switch that is triggered by CD2AP and oscillates between inhibition and promotion of Ret degradation. |
| 3 | 18753381 | Consistent with the hypothesis, Cbl-3 silencing in neurons only inhibited Ret degradation and enhanced neuronal survival in combination with CD2AP silencing. |