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Gene Information
Gene symbol: CCR2
Gene name: chemokine (C-C motif) receptor 2
HGNC ID: 1603
Synonyms: CC-CKR-2, CKR2, MCP-1-R, CD192, FLJ78302
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALB | 1 hits |
| 2 | CCL2 | 1 hits |
| 3 | CNR2 | 1 hits |
| 4 | PIK3CA | 1 hits |
| 5 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19420107 | The TGF-beta-induced MCP-1 was found to activate the podocyte's cysteine-cysteine chemokine receptor 2 (CCR2) and, as a result, enhance the cellular motility, cause rearrangement of the actin cytoskeleton, and increase podocyte permeability to albumin in a Transwell assay. |
| 2 | 19420107 | The preceding effects of TGF-beta were replicated by treatment with recombinant MCP-1 and blocked by a neutralizing anti-MCP-1 antibody or a specific CCR2 inhibitor, RS102895. |
| 3 | 19420107 | In conclusion, this is the first description that TGF-beta signaling through PI3K induces the podocyte expression of MCP-1 that can then operate via CCR2 to increase cellular migration and alter albumin permeability characteristics. |
| 4 | 21810593 | In addition, AM1241 reduced CCR2 expression in both renal cortex and cultured podocytes, suggesting that CB2 activation may interfere with the deleterious effects of MCP-1 signaling. |