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Gene Information

Gene symbol: CD2AP

Gene name: CD2-associated protein

HGNC ID: 14258

Synonyms: CMS

Related Genes

# Gene Symbol Number of hits
1 AKT1 1 hits
2 CBLC 1 hits
3 DDN 1 hits
4 GDNF 1 hits
5 INPPL1 1 hits
6 INS 1 hits
7 LMX1B 1 hits
8 NPHS1 1 hits
9 NPHS2 1 hits
10 PIK3CA 1 hits
11 PIK3R1 1 hits
12 RAC1 1 hits
13 SH3KBP1 1 hits
14 SMAD2 1 hits
15 SMAD3 1 hits
16 SYNPO 1 hits
17 TGFB1 1 hits

Related Sentences

# PMID Sentence
1 12832477 We demonstrate that both nephrin and CD2AP interact with the p85 regulatory subunit of phosphoinositide 3-OH kinase (PI3K) in vivo, recruit PI3K to the plasma membrane, and, together with podocin, stimulate PI3K-dependent AKT signaling in podocytes.
2 16280470 In the case of the podocyte line, differentiation occurred on all three matrices as indicated by the expression of synaptopodin and CD2-associated protein (CD2AP) and organization of myosin heavy chain IIA into a linear pattern.
3 17606992 CIN85 is expressed as multiple isoforms that share the CC domain, suggesting that heterotypic interactions with CMS provides a mechanism to regulate CMS binding to F-actin and thus for modulating dynamic rearrangements of the cytoskeleton.
4 18753381 After Ret activation by GDNF, CD2AP dissociates.
5 18753381 In contrast to their dissociation from autophosphorylated Ret, an interaction between CD2AP and Cbl-3 is induced by GDNF stimulation of sympathetic neurons, suggesting that CD2AP and Cbl-3 dissociate from Ret as a complex.
6 18753381 In neurons, the overexpression of CD2AP enhances the degradation of Ret and inhibits GDNF-dependent survival, and gene silencing of CD2AP blocks Ret degradation and promotes GDNF-mediated survival.
7 18753381 In combination with CD2AP, however, Cbl-3 promotes Ret degradation rapidly and almost completely blocks survival promotion by GDNF, suggesting that Cbl-3 acts as a switch that is triggered by CD2AP and oscillates between inhibition and promotion of Ret degradation.
8 18753381 Consistent with the hypothesis, Cbl-3 silencing in neurons only inhibited Ret degradation and enhanced neuronal survival in combination with CD2AP silencing.
9 19679673 TGF-beta promotes proapoptotic signaling mediated by Smad3 but also activates prosurvival pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the latter requires the CD2-associated adaptor protein (CD2AP) in podocytes.
10 19679673 Here, we report that CD2AP-dependent early activation of the antiapoptotic PI3K/AKT pathway does not require TGF-beta receptor-regulated Smad2 and Smad3.
11 19679673 We found that the C-terminal region of CD2AP interacts directly with the cytoplasmic tail of the TGF-beta receptor type I (TbetaRI) in a kinase-dependent manner and that the interaction between the TbetaRI and the p85 subunit of PI3K requires CD2AP.
12 19679673 In vivo, to determine the effects of reduced Smad3 or CD2AP gene dosage on podocyte apoptosis and proteinuria characteristic of TGF-beta1 transgenic mice, we generated TGF-beta1 transgenic mice deficient for Smad3 or heterozygous for CD2AP.
13 19679673 Smad3 deficiency ameliorated podocyte apoptosis, and CD2AP heterozygosity increased both podocyte apoptosis and proteinuria.
14 18535845 NPHS2, CD2AP), the transription of which is regulated by LMX1B.
15 20404345 Here, CD2AP links the cell adhesion protein nephrin to the actin cytoskeleton.
16 20404345 We found that CD2AP specifically interacts with the C-terminal domain of Rac1 but not with that of other Rho family members.
17 20404345 Finally, expression of constitutive active Rac1 recruits CD2AP to cell-cell contacts in epithelial cells, where we found CD2AP to participate in the control of the epithelial barrier function.
18 20654688 To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
19 20654688 SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation.
20 10997929 CD2-associated protein (CD2AP) is an adapter molecule that can bind to the cytoplasmic domain of nephrin, a component of the glomerular slit diaphragm.
21 10997929 Kidneys from Cd2ap -/- mice initially exhibited normal nephrin localization, but as the mice aged and foot processes became effaced, nephrin disappeared.
22 20457601 We can demonstrate that the loss of nephrin expression and onset of the proteinuria in CD2AP(-/-) mice correlates with an increased accumulation of ubiquitinated proteins and expression of CIN85/Ruk(L) in podocytes.
23 20457601 In cultured murine podocytes CD2AP deficiency leads to an early ubiquitination of nephrin and podocin after stimulation with fibroblast growth factor-4.
24 21911934 Here, we have shown that CD2AP regulates the TGF-?1-dependent translocation of dendrin from the SD to the nucleus.