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Gene Information
Gene symbol: DES
Gene name: desmin
HGNC ID: 2770
Synonyms: CMD1I, CSM1, CSM2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALB | 1 hits |
| 2 | IGFBP7 | 1 hits |
| 3 | ILK | 1 hits |
| 4 | MGA | 1 hits |
| 5 | NPHS1 | 1 hits |
| 6 | NPHS2 | 1 hits |
| 7 | PDPN | 1 hits |
| 8 | SYNPO | 1 hits |
| 9 | VIM | 1 hits |
| 10 | WNT1 | 1 hits |
| 11 | WT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21893018 | Immunofluorescence analysis showed that the FF diet decreased the expression of podocin but increased desmin and ceramide levels in glomeruli from Asm(+/+) mice but not in those from Asm(-/-) and Asm shRNA-transfected wild-type mice. |
| 2 | 8396229 | CCSK cells consistently exhibited moderate to strong diffuse cytoplasmic positivity for VIM and were negative for F8A, EMA, DES, S-100 and Mac 387. |
| 3 | 16120817 | Similar to Tg26 kidneys, podocytes in kd/kd kidneys showed de novo cyclin D1, Ki-67, and desmin expression with loss of synaptopodin and WT-1 expression. |
| 4 | 20630940 | IGFBP-rP1 was absent from podocytes of normal mice and was expressed in podocytes and pseudocrescents of transgenic mice, where it was coexpressed with desmin, a podocyte injury marker. |
| 5 | 20505657 | Ectopic expression of ILK in podocytes decreased levels of the epithelial markers nephrin and ZO-1, induced mesenchymal markers such as desmin, fibronectin, matrix metalloproteinase-9 (MMP-9), and alpha-smooth muscle actin (alpha-SMA), promoted cell migration, and increased the paracellular albumin flux across podocyte monolayers. |
| 6 | 20962747 | Glomerulosclerosis in these mice was associated with the expression of desmin and the loss of nephrin, markers of podocyte damage and apoptosis. |
| 7 | 18199599 | Albuminuria developed starting at 6 wk of age and coincided with focal and segmental loss of podoplanin, increased expression of desmin, entrapment of albumin in affected podocytes, and focal and segmental foot process effacement at the ultrastructural level. |
| 8 | 20116427 | Hyperhomocysteinemia-induced decrease in nephrin expression and increase in desmin expression in gp91(+/+) mice were not observed in gp91(-/-) mice. |
| 9 | 21220752 | Immunostaining for Wilms' tumor-1 (WT1) and synaptopodin, markers of podocytes, was attenuated, whereas immunostaining for desmin, a marker of podocyte damage, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, was up-regulated in the glomeruli of diabetic rats. |
| 10 | 17722705 | We conclude that the expression of desmin in podocytes is upregulated in patients with IMN as compared to other glomerular diseases including MCNS or MGA, or to controls. |
| 11 | 21832980 | In vivo, ectopic expression of TGF-?1 induced Wnt1 expression, activated ?-catenin, and upregulated Wnt target genes such as Snail1, MMP-7, MMP-9, desmin, Fsp1, and PAI-1 in mouse glomeruli, leading to podocyte injury and albuminuria. |