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Gene Information

Gene symbol: EDN1

Gene name: endothelin 1

HGNC ID: 3176

Synonyms: ET1

Related Genes

# Gene Symbol Number of hits
1 ACE 1 hits
2 ALB 1 hits
3 AR 1 hits
4 EDNRA 1 hits
5 EDNRB 1 hits
6 NPHS1 1 hits

Related Sentences

# PMID Sentence
1 16449275 It was the purpose of the present study to analyse by immunohistology the expression of ET-1 as well as of the two ET receptors (ET-RA and ET-RB) in the different cells and compartments of kidney grafts and control kidneys.
2 18287402 Indeed, ET-1 was synthesized and released from glomerular endothelial cells when incubated with PE sera, and recombinant ET-1 triggered nephrin shedding from podocytes.
3 18287402 Moreover, VEGF blockade induced ET-1 release from endothelial cells, and in turn the conditioned medium obtained triggered nephrin loss.
4 18648345 There is strong evidence that endothelin-1, a peptide with growth-promoting and vasoconstricting properties, has a central role in the pathogenesis of proteinuria and glomerulosclerosis, which is mediated via activation of the ET(A) receptor.
5 18648345 Several antiproteinuric drugs, including angiotensin-converting-enzyme inhibitors, angiotensin receptor antagonists, statins and certain calcium channel blockers, inhibit the formation of endothelin-1.
6 21893994 Because podocytes are cells in the glomerulus that form a crucial component of the glomerular filtration barrier, contributing to size selectivity and maintaining a large filtration surface, we focus on evidence that suggest ET-1 may promote podocyte injury thereby aggravating albumin urinary loss and alteration of the glomerular microvasculature.