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Gene Information

Gene symbol: EGFR

Gene name: epidermal growth factor receptor

HGNC ID: 3236

Synonyms: ERBB1

Related Genes

# Gene Symbol Number of hits
1 ADAM17 1 hits
2 AGT 1 hits
3 BDKRB2 1 hits
4 EGF 1 hits
5 EREG 1 hits
6 JAK2 1 hits
7 MAPK1 1 hits
8 SLC9A1 1 hits
9 TGFA 1 hits
10 TJP1 1 hits

Related Sentences

# PMID Sentence
1 19341767 The EGFR kinase inhibitor, AG1478, blocked activation of NHE-1, but did not block EGF-induced phosphorylation of Jak2 or CaM.
2 19341767 These results suggest that EGF induces NHE-1 activity in podocytes through two pathways: (1) EGF-->EGFR-->Jak2 activation (independent of EGFR tyrosine kinase activity)-->tyrosine phosphorylation of CaM-->CaM binding to NHE-1-->conformational change of NHE-1-->activation of NHE-1; and (2) EGF-->EGFR-->EGFR kinase activation-->association of CaM with NHE-1 (independent of Jak2)-->conformational change of NHE-1-->activation of NHE-1.
3 20566668 We show that BK2 receptor (BK2R) stimulation transactivates the epidermal growth factor receptor (EGFR).
4 20566668 EGFR transactivation is mediated by a disintegrin and metalloenzyme (ADAM) family members, which are required for both extracellular signal-regulated kinase (ERK) and EGFR activation by BK.
5 20566668 Using a gene-silencing approach we observed that both BK-induced ERK activation and BK-induced permeability decrease in podocytes is attenuated by ADAM17 down-regulation, and we identified epiregulin (ER) as the EGFR ligand participating in ADAM-dependent BK2R-EGFR cross-talk.
6 20566668 We propose that ZO-1 redistribution is an important element of BK-induced permeability change and the signaling events involved in ZO-1 rearrangement include transactivation of the EGFR via ADAM17 activation and ER shedding.
7 19535569 A disintegrin and metalloproteinase (ADAM)17 sheds growth factors from the cell membrane, including epidermal growth factor receptor (EGFR) ligand transforming growth factor (TGF)-alpha.
8 19535569 In mice, angiotensin II infusion induces renal fibrosis via ADAM17-mediated TGF-alpha shedding and subsequent EGFR activation.