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Gene Information
Gene symbol: GDNF
Gene name: glial cell derived neurotrophic factor
HGNC ID: 4232
Synonyms: ATF1, ATF2, HFB1-GDNF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CBLC | 1 hits |
| 2 | CD2AP | 1 hits |
| 3 | PCNA | 1 hits |
| 4 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18249526 | Additional studies revealed that SEMA3A effects on ureteric bud branching involve downregulation of glial cell-line derived neurotrophic factor (GDNF) signaling, competition with vascular endothelial growth factor A (VEGF-A) and decreased activity of Akt survival pathways. |
| 2 | 18753381 | After Ret activation by GDNF, CD2AP dissociates. |
| 3 | 18753381 | In contrast to their dissociation from autophosphorylated Ret, an interaction between CD2AP and Cbl-3 is induced by GDNF stimulation of sympathetic neurons, suggesting that CD2AP and Cbl-3 dissociate from Ret as a complex. |
| 4 | 18753381 | In neurons, the overexpression of CD2AP enhances the degradation of Ret and inhibits GDNF-dependent survival, and gene silencing of CD2AP blocks Ret degradation and promotes GDNF-mediated survival. |
| 5 | 18753381 | In combination with CD2AP, however, Cbl-3 promotes Ret degradation rapidly and almost completely blocks survival promotion by GDNF, suggesting that Cbl-3 acts as a switch that is triggered by CD2AP and oscillates between inhibition and promotion of Ret degradation. |
| 6 | 20943767 | Compensatory glomerular hypertrophy in GDNF+/- was accompanied by higher numbers of endothelial and mesangial cells as well as PCNA-positive glomerular cells, whereas podocyte density was significantly reduced. |