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Gene Information
Gene symbol: GRB2
Gene name: growth factor receptor-bound protein 2
HGNC ID: 4566
Synonyms: NCKAP2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | KIRREL | 1 hits |
| 2 | MAPK1 | 1 hits |
| 3 | NPHS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18258597 | In pull-down assays using rat glomerular lysates, Neph1 but not nephrin specifically binds to adaptor protein Grb2 and tyrosine kinase Csk in a phosphorylation-dependent manner. |
| 2 | 18258597 | Furthermore, Neph1 attenuates ERK activation elicited by Fyn, and this inhibitory effect requires the intact binding motif for the Grb2 SH2 domain. |
| 3 | 18258597 | Our results shown here demonstrate that Neph1 is a novel in vivo substrate of SFK and suggest that Neph1 modulates ERK signaling through phosphorylation-dependent interaction with Grb2. |