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Gene Information
Gene symbol: ILK
Gene name: integrin-linked kinase
HGNC ID: 6040
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALB | 1 hits |
| 2 | DES | 1 hits |
| 3 | ITK | 1 hits |
| 4 | LIMS1 | 1 hits |
| 5 | MMP9 | 1 hits |
| 6 | NPHS1 | 1 hits |
| 7 | NPHS2 | 1 hits |
| 8 | OSGEP | 1 hits |
| 9 | PARVA | 1 hits |
| 10 | PARVB | 1 hits |
| 11 | PTK2 | 1 hits |
| 12 | TGFB1 | 1 hits |
| 13 | TJP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16314921 | In contrast to PARVA, PARVB inhibits ILK activity and reverses some of its oncogenic effects in cancer cells. |
| 2 | 16837631 | ILK deficiency caused an aberrant distribution of nephrin and alpha-actinin-4 in podocytes, whereas the localization of podocin and synaptopodin remained relatively intact. |
| 3 | 16837631 | Co-immunoprecipitation demonstrated that ILK physically interacted with nephrin to form a ternary complex, and alpha-actinin-4 participated in ILK/nephrin complex formation. |
| 4 | 20576809 | In kidneys of Ae1(-/-) mice, nephrin abundance was normal but its distribution was altered along with the reported kAE1-binding protein integrin-linked kinase (ILK). |
| 5 | 20576809 | Glomeruli with ILK-deficient podocytes also demonstrated altered AE1 and nephrin expression, further supporting the functional interdependence of these proteins. |
| 6 | 20576809 | These data suggest that the podocyte protein kAE1 interacts with nephrin and ILK to maintain the structure and function of the glomerular basement membrane. |
| 7 | 20505657 | ILK expression was induced in mouse podocytes by various injurious stimuli known to cause proteinuria including TGF-beta1, adriamycin, puromycin, and high ambient glucose. |
| 8 | 20505657 | Ectopic expression of ILK in podocytes decreased levels of the epithelial markers nephrin and ZO-1, induced mesenchymal markers such as desmin, fibronectin, matrix metalloproteinase-9 (MMP-9), and alpha-smooth muscle actin (alpha-SMA), promoted cell migration, and increased the paracellular albumin flux across podocyte monolayers. |
| 9 | 20505657 | ILK also induced Snail, a key transcription factor mediating epithelial-mesenchymal transition (EMT). |
| 10 | 20505657 | Blockade of ILK activity with a highly selective small molecule inhibitor reduced Snail induction and preserved podocyte phenotypes following TGF-beta1 or adriamycin stimulation. |
| 11 | 20505657 | In vivo, this ILK inhibitor ameliorated albuminuria, repressed glomerular induction of MMP-9 and alpha-SMA, and preserved nephrin expression in murine adriamycin nephropathy. |
| 12 | 20505657 | Our results show that upregulation of ILK is a convergent pathway leading to podocyte EMT, migration, and dysfunction. |
| 13 | 18480182 | The PINCH-1-integrin-linked kinase (ILK)-alpha-parvin (PIP) complex plays important roles in the regulation of glomerular cell behavior, including podocyte shape change, apoptosis, and mesangial fibronectin matrix deposition. |
| 14 | 21705647 | Western blotting analysis revealed that the protein levels of FAK, p-FAK(397), paxillin, p-paxillin(118), and Hic-5 were high in embryonic kidneys, while ILK expression persisted from the embryonic to the mature stage. |