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Gene Information
Gene symbol: INPPL1
Gene name: inositol polyphosphate phosphatase-like 1
HGNC ID: 6080
Synonyms: SHIP2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD2AP | 1 hits |
| 2 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20654688 | To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling. |
| 2 | 20654688 | SHIP2 interacts with CD2AP in glomeruli and is expressed in podocytes, where it translocates to plasma membrane after insulin stimulation. |
| 3 | 20654688 | Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis. |
| 4 | 20654688 | These results indicate that SHIP2 downregulates insulin signalling in podocytes. |