Ignet
Search (e.g., vaccine, IFNG): Help
About
Home
Introduction
Statistics
Programs
Dignet
Gene
GenePair
Help & Docs
Documents
Help
FAQs
Links
Acknowledge
Disclaimer
Contact Us
UM Logo

UMMS Logo

UMMS Logo

Gene Information

Gene symbol: INS

Gene name: insulin

HGNC ID: 6081

Related Genes

# Gene Symbol Number of hits
1 ADIPOQ 1 hits
2 AGT 1 hits
3 AKT1 1 hits
4 CD2AP 1 hits
5 DUOX1 1 hits
6 INPPL1 1 hits
7 NPHS1 1 hits
8 NR3C2 1 hits
9 RETN 1 hits
10 SLC2A8 1 hits
11 SREBF1 1 hits
12 SREBF2 1 hits

Related Sentences

# PMID Sentence
1 15741607 Additionally, GLUT8 expression was studied using two different models of insulin resistance, GLUT4-/- and db/db mice.
2 19261739 Recent evidence suggests that mineralocorticoid receptor (MR) antagonism has beneficial effects on tissue oxidative stress and insulin metabolic signaling as well as reducing proteinuria.
3 20654688 To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling.
4 20654688 Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
5 20654688 These results indicate that SHIP2 downregulates insulin signalling in podocytes.
6 21177830 The vasodilator ?-blocker nebivolol reduces nicotinamide adenine dinucleotide phosphate oxidase activity, increases bioavailable nitric oxide, and improves insulin sensitivity.
7 21177830 Compared with Zucker lean, ZO controls exhibited increased proteinuria and ?-glutamyl transpeptidase, reductions in systemic insulin sensitivity in association with increased renal renin, (pro)renin receptor, angiotensin II type 1 receptor, and mineralocorticoid receptor immunostaining, oxidative stress, and glomerular tubular structural abnormalities that were substantially improved with in vivo nebivolol treatment.
8 21209008 Diet-induced obesity (DIO) and insulin resistance in mice are associated with proteinuria, renal mesangial expansion, accumulation of extracellular matrix proteins, and activation of oxidative stress, proinflammatory cytokines, profibrotic growth factors, and the sterol regulatory element binding proteins, SREBP-1 and SREBP-2, that mediate increases in fatty acid and cholesterol synthesis.
9 19833886 Actin stabilization prevented nephrin trafficking as well as nephrin-positive effect on insulin release.
10 21660954 High glucose treatment also abolished the stimulatory effects of insulin on BK(Ca) current density, although insulin continued to increase phosphorylation of Erk and Akt under those conditions.
11 21694920 Adiponectin potentiates insulin in its post-receptor signaling resulting in glucose oxidation in mitochondria.
12 21694920 Fatty acid accumulation and resistin inhibit insulin and adiponectin.