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Gene Information
Gene symbol: JAK2
Gene name: Janus kinase 2
HGNC ID: 6192
Synonyms: JTK10
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EGF | 1 hits |
| 2 | EGFR | 1 hits |
| 3 | SLC9A1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19341767 | Furthermore, pharmacological inhibitors of Janus kinase (Jak2) and calmodulin (CaM) attenuated EGF-induced NHE-1 activity. |
| 2 | 19341767 | The EGFR kinase inhibitor, AG1478, blocked activation of NHE-1, but did not block EGF-induced phosphorylation of Jak2 or CaM. |
| 3 | 19341767 | These results suggest that EGF induces NHE-1 activity in podocytes through two pathways: (1) EGF-->EGFR-->Jak2 activation (independent of EGFR tyrosine kinase activity)-->tyrosine phosphorylation of CaM-->CaM binding to NHE-1-->conformational change of NHE-1-->activation of NHE-1; and (2) EGF-->EGFR-->EGFR kinase activation-->association of CaM with NHE-1 (independent of Jak2)-->conformational change of NHE-1-->activation of NHE-1. |