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Gene Information

Gene symbol: KDR

Gene name: kinase insert domain receptor (a type III receptor tyrosine kinase)

HGNC ID: 6307

Synonyms: FLK1, VEGFR, VEGFR2, CD309

Related Genes

# Gene Symbol Number of hits
1 NPHS1 1 hits
2 NPTX1 1 hits
3 NPTX2 1 hits
4 VEGFA 1 hits
5 VEGFC 1 hits

Related Sentences

# PMID Sentence
1 22038228 The aim of the present work was to analyze the possible relation between VEGF-C and VEGF receptor (VEGFR)-2 expressions at electron microscopy level in different INS cases.
2 22038228 VEGF-C over-expression in these cases was followed by downregulation of VEGFR-2.
3 16239266 The VEGF-induced elevation of LpA/Vi was blocked by the selective VEGF-R2 inhibitor ZM323881.
4 16436677 Additionally, VEGFR2 was constitutively phosphorylated in the liver, lung, adipose, and kidney in vivo, providing evidence consistent with a role for VEGF in adult tissues.
5 20688931 Unlike cell culture models, enhanced expression of VEGF by podocytes in vivo caused foot process fusion and alterations in slit diaphragm-associated proteins; however, inhibition of VEGFR-2 could not rescue this defect.
6 12620928 Normal human podocytes are also known to express neuropilin-1, VEGF, and are VEGF-R2 negative.
7 16597608 Differentiated podocytes expressed eightfold higher VEGFR2 mRNA levels than undifferentiated podocytes, whereas VEGFR1, sVEGFR1, NP1, and NP2 mRNA levels were similar.
8 16597608 VEGF(165) induced a twofold increase in VEGFR2 mRNA and protein levels, whereas VEGFR1, sVEGFR1, NP1, and NP2 mRNA levels remained unchanged.
9 16597608 VEGF(165) induced VEGFR2 phosphorylation.
10 19828679 We demonstrated that ablation of VEGF-A or VEGF-C as well as treatment with bevacizumab or a VEGFR-2/-3 tyrosine kinase inhibitor led to reduced podocyte survival.
11 21937443 We previously showed that in vivo nephrin associates with VEGF receptor-2 (VEGFR2), the signaling receptor for VEGF-A.