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Gene Information
Gene symbol: KIRREL
Gene name: kin of IRRE like (Drosophila)
HGNC ID: 15734
Synonyms: NEPH1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GRB2 | 1 hits |
| 2 | KCNMA1 | 1 hits |
| 3 | MAPK1 | 1 hits |
| 4 | MYO1C | 1 hits |
| 5 | NPHS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19794150 | Here we show that Slo1 proteins interact with Neph1, a member of the immunoglobulin superfamily expressed in slit diaphragm domains of podocytes and in vertebrate and invertebrate nervous systems. |
| 2 | 19794150 | Neph1 can interact with all three extreme COOH-terminal variants of Slo1 (Slo1(VEDEC), Slo1(QEERL), and Slo1(EMVYR)) as ascertained by glutathione S-transferase (GST) pull-down assays and by coimmunoprecipitation. |
| 3 | 19794150 | Neph1 is partially colocalized in intracellular compartments with endogenous Slo1 in podocytes and ciliary ganglion neurons. |
| 4 | 19794150 | Consistent with this, small interfering RNA (siRNA) knockdown of endogenous Neph1 in embryonic day 10 ciliary ganglion neurons causes an increase in steady-state surface expression of Slo1 and an increase in whole cell Ca(2+)-dependent K(+) current. |
| 5 | 19794150 | Surprisingly, a comparable Neph1 knockdown in podocytes causes a decrease in surface expression of Slo1 and a decrease in whole cell BK(Ca) currents. |
| 6 | 19794150 | In podocytes, Neph1 siRNA also caused a decrease in nephrin, even though the Neph1 siRNA had no sequence homology with nephrin. |
| 7 | 21402783 | Unlike wild-type Myo1c, the membrane localization of Neph1 was significantly reduced in podocytes expressing dominant negative Myo1c. |
| 8 | 21402783 | We further demonstrate that similarly to Neph1, Myo1c also binds nephrin and reduces its localization at the podocyte cell membrane. |
| 9 | 18258597 | Furthermore, Neph1 attenuates ERK activation elicited by Fyn, and this inhibitory effect requires the intact binding motif for the Grb2 SH2 domain. |
| 10 | 18258597 | Our results shown here demonstrate that Neph1 is a novel in vivo substrate of SFK and suggest that Neph1 modulates ERK signaling through phosphorylation-dependent interaction with Grb2. |