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Gene Information

Gene symbol: MAGI1

Gene name: membrane associated guanylate kinase, WW and PDZ domain containing 1

HGNC ID: 946

Synonyms: BAP1, MAGI-1, TNRC19, AIP3, WWP3

Related Genes

#	Gene Symbol	Number of hits
1	ACTN4	1 hits
2	CTNNB1	1 hits
3	KCNMA1	1 hits
4	NPHS1	1 hits
5	PTPRO	1 hits
6	SDK1	1 hits

Related Sentences

#	PMID	Sentence
1	11274227	Immunofluorescence studies of adult kidney revealed that MAGI-1 is expressed in the glomerulus of the kidney, in a manner that parallels the expression of the podocyte-specific protein glomerular epithelial protein 1.
2	16155592	Biochemical studies reveal that nephrin directly binds to the middle PDZ domains of MAGI-1 through its carboxyl terminus but does not bind to ZO-1.
3	16155592	MAGI-1 forms a tripartite complex with nephrin and JAM4 in vitro.
4	19403801	Partial knockdown of endogenous MAGI-1 expression by small interfering RNA (siRNA) in differentiated podocytes increased the surface expression of endogenous Slo1 as assessed by electrophysiology and cell-surface biotinylation assays, whereas overexpression of MAGI-1a reduced steady-state voltage-evoked outward current through podocyte BK(Ca) channels.
5	20562105	We also show that sdk-1 associates with the slit diaphragm linker protein MAGI-1, which is already known to interact with several critical podocyte proteins including synaptopodin, alpha-actinin-4, nephrin, JAM4, and beta-catenin.
6	20562105	Furthermore, a truncated version of sdk-1 that is unable to bind to MAGI-1 does not induce podocyte dysfunction when overexpressed.
7	20562105	We conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in FSGS and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function.