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Gene Information

Gene symbol: MMP9

Gene name: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

HGNC ID: 7176

Related Genes

#	Gene Symbol	Number of hits
1	COL1A1	1 hits
2	ILK	1 hits
3	MMP2	1 hits
4	NPHS1	1 hits
5	SMAD2	1 hits
6	WNT1	1 hits

Related Sentences

#	PMID	Sentence
1	16061020	The MMP9 activity in the supernatant of the HG group had a strongly negative correlation with the levels of collagen alpha5 (IV) protein (r = -0.577, P < 0.006).
2	16061020	Pretreatment with PD98059, for 30 min abolished the HG-stimulated increase of MMP-9 activity and MMP-9 mRNA, as well as the decrease of collagen alpha5 (IV) protein.
3	16301820	However, blockade of Smad2 signaling pathway by Staurosporine did not affect the TGFbeta1-stimulated secretion of MMP-9, whereas inhibition of activation of ERK1/2 by PD98059 abolished TGFbeta1-stimulated secretion of MMP-9 and expression of MMP-9 mRNA.
4	20505657	Ectopic expression of ILK in podocytes decreased levels of the epithelial markers nephrin and ZO-1, induced mesenchymal markers such as desmin, fibronectin, matrix metalloproteinase-9 (MMP-9), and alpha-smooth muscle actin (alpha-SMA), promoted cell migration, and increased the paracellular albumin flux across podocyte monolayers.
5	20505657	In vivo, this ILK inhibitor ameliorated albuminuria, repressed glomerular induction of MMP-9 and alpha-SMA, and preserved nephrin expression in murine adriamycin nephropathy.
6	21228599	ALI had no effect on MMP2 mRNA or protein or MMP9 mRNA tested under HG conditions.
7	21832980	In vivo, ectopic expression of TGF-?1 induced Wnt1 expression, activated ?-catenin, and upregulated Wnt target genes such as Snail1, MMP-7, MMP-9, desmin, Fsp1, and PAI-1 in mouse glomeruli, leading to podocyte injury and albuminuria.