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Gene Information
Gene symbol: NOTCH1
Gene name: notch 1
HGNC ID: 7881
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NOTCH2 | 1 hits |
| 2 | NPHS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20522599 | After use of pharmacological modulators or specific shRNA knockdown strategies, inhibition of Notch-1 signaling significantly abrogated VEGF activation and nephrin repression in HG-stressed cells and ameliorated proteinuria in the diabetic kidney. |
| 2 | 20522599 | Our findings suggest that upregulation of Notch-1 signaling in HG-treated renal podocytes induces VEGF expression and subsequent nephrin repression and apoptosis. |
| 3 | 17229764 | Genetic analysis reveals that only Notch2 is required for the differentiation of proximal nephron structures (podocytes and proximal convoluted tubules) despite the presence of activated Notch1 in the nuclei of putative proximal progenitors. |