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Gene Information
Gene symbol: NOX4
Gene name: NADPH oxidase 4
HGNC ID: 7891
Synonyms: KOX-1, KOX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAT | 1 hits |
| 2 | NOX5 | 1 hits |
| 3 | PRKAA1 | 1 hits |
| 4 | SOD1 | 1 hits |
| 5 | STN | 1 hits |
| 6 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18172055 | Angiotensin II-dependent increases in podocyte NADPH oxidase activity and subunit expression (NOX2, NOX4, Rac, and p22(phox)) and reactive oxygen species generation were decreased after in vitro statin treatment. |
| 2 | 20861022 | Here, we show that HG inactivates AMP-activated protein kinase (AMPK), up-regulates Nox4, enhances NADPH oxidase activity, and induces podocyte apoptosis. |
| 3 | 20861022 | Activation of AMPK blocked HG-induced expression of Nox4, NADPH oxidase activity, and apoptosis. |
| 4 | 20861022 | Inactivation of AMPK by HG up-regulated the expression and phosphorylation of p53, and p53 acted downstream of Nox4. |
| 5 | 20861022 | Glomeruli isolated from these mice showed decreased phosphorylation of AMPK and enhanced expression of Nox4 and p53. |
| 6 | 20861022 | Our results uncover a novel function of AMPK that integrates metabolic input to Nox4 and provide new insight for activation of p53 to induce podocyte apoptosis. |
| 7 | 21503956 | We found long-term (3 and 5 days) exposure of mouse podocytes to high glucose concentrations caused oxidative stress, as evidenced by increased expression of Nox4 and activities of NAD(P)H oxidase (? 182%) and SOD (? 39%) and decreased activities of GPx (? -40%) and CAT (? -35%). |