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Gene Information
Gene symbol: NOX5
Gene name: NADPH oxidase, EF-hand calcium binding domain 5
HGNC ID: 14874
Synonyms: NOX5A, NOX5B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGT | 1 hits |
| 2 | AKT1 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | CYBA | 1 hits |
| 5 | CYBB | 1 hits |
| 6 | MAPK14 | 1 hits |
| 7 | NOX1 | 1 hits |
| 8 | NOX4 | 1 hits |
| 9 | NPHS2 | 1 hits |
| 10 | PRKAA1 | 1 hits |
| 11 | PRKAA2 | 1 hits |
| 12 | SGK1 | 1 hits |
| 13 | SYNPO | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16380497 | Increased extracellular glucose (30 mmol/l) rapidly stimulated generation of intracellular reactive oxygen species (ROS) through NADPH oxidase and mitochondrial pathways and led to activation of proapoptotic p38 mitogen-activated protein kinase and caspase 3 and to apoptosis of conditionally immortalized podocytes in vitro. |
| 2 | 16987014 | NADPH oxidase activity is upregulated by prolonged infusion of angiotensin II (Ang II) or a high salt diet. |
| 3 | 16987014 | Indeed, recent studies with small interference RNAs (siRNAs) targeted to p22( phox ) implicate p22( phox ) in Ang II-induced activation of renal NADPH oxidase and the development of oxidative stress and hypertension, while studies with apocynin implicate activation of p47( phox ) in the development of nephropathy in a rat model of type 1 diabetes mellitus (DM). |
| 4 | 18172055 | Angiotensin II-dependent increases in podocyte NADPH oxidase activity and subunit expression (NOX2, NOX4, Rac, and p22(phox)) and reactive oxygen species generation were decreased after in vitro statin treatment. |
| 5 | 18431508 | These effects seemed to be caused by reduction of oxidative stress, as adiponectin and AMPK activation both reduced protein levels of the NADPH oxidase Nox4 in podocytes. |
| 6 | 19208908 | Treatment of OVE26 mice with HET0016 decreased NADPH oxidase activity and Nox1 and Nox4 protein expression and ameliorated apoptosis and albuminuria. |
| 7 | 19261739 | Albuminuria, podocyte-specific proteins (synaptopodin, nephrin, and podocin), and ultrastructural analysis of the glomerular filtration barrier were measured in relation to RAAS activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, reactive oxygen species (ROS), and the redox-sensitive Rho kinase (ROK). |
| 8 | 20596957 | Chronic inhibition of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats. |
| 9 | 20861022 | Here, we show that HG inactivates AMP-activated protein kinase (AMPK), up-regulates Nox4, enhances NADPH oxidase activity, and induces podocyte apoptosis. |
| 10 | 20861022 | Activation of AMPK blocked HG-induced expression of Nox4, NADPH oxidase activity, and apoptosis. |
| 11 | 20007350 | Structural and functional alterations were accompanied by increased renal cortical ANG II, AT1R, as well as NADPH oxidase subunit (Nox2) expression compared with SD controls. |
| 12 | 21220752 | In cultured MR-expressing podocytes, high glucose significantly enhanced Sgk1 expression, activated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and ROS production and induced podocyte apoptosis. |