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Gene Information
Gene symbol: PDPN
Gene name: podoplanin
HGNC ID: 29602
Synonyms: T1A-2, Gp38, aggrus, GP40, PA2.26
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CLEC1B | 1 hits |
| 2 | DES | 1 hits |
| 3 | PROX1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18215137 | The transmembrane protein podoplanin was identified on HEK-293T cells and was demonstrated to mediate both binding of HEK-293T cells to CLEC-2 and HEK-293T cell activation of CLEC-2-transfected DT-40 B-cells. |
| 2 | 18215137 | The present study identifies podoplanin as a ligand for CLEC-2 on renal cells. |
| 3 | 19031946 | The expression of podoplanin is induced by the homeobox gene Prox-1 and a specific endogenous receptor was identified on platelets. |
| 4 | 18199599 | Albuminuria developed starting at 6 wk of age and coincided with focal and segmental loss of podoplanin, increased expression of desmin, entrapment of albumin in affected podocytes, and focal and segmental foot process effacement at the ultrastructural level. |
| 5 | 21781241 | The endogenous ligand of CLEC-2 has been identified as podoplanin, which is expressed on the surface of tumour cells and facilitates tumour metastasis by inducing platelet activation. |
| 6 | 21781241 | In the developmental stages, when the primary lymph sac is derived from the cardinal vein, podoplanin activates platelets in lymphatic endothelial cells by binding to CLEC-2, which facilitates blood/lymphatic vessel separation. |