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Gene Information
Gene symbol: PIK3CA
Gene name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
HGNC ID: 8975
Synonyms: PI3K
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CCR2 | 1 hits |
| 3 | CD2AP | 1 hits |
| 4 | CD59 | 1 hits |
| 5 | NPHS1 | 1 hits |
| 6 | NPHS2 | 1 hits |
| 7 | PIK3R1 | 1 hits |
| 8 | TGFB1 | 1 hits |
| 9 | TJP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12832477 | We demonstrate that both nephrin and CD2AP interact with the p85 regulatory subunit of phosphoinositide 3-OH kinase (PI3K) in vivo, recruit PI3K to the plasma membrane, and, together with podocin, stimulate PI3K-dependent AKT signaling in podocytes. |
| 2 | 15843472 | Nephrin reduction was preceded by inhibition of nephrin tyrosine phosphorylation and of its association with p85 phosphatidylinositol 3-kinase (PI3K). |
| 3 | 19420107 | In conclusion, this is the first description that TGF-beta signaling through PI3K induces the podocyte expression of MCP-1 that can then operate via CCR2 to increase cellular migration and alter albumin permeability characteristics. |
| 4 | 19679673 | TGF-beta promotes proapoptotic signaling mediated by Smad3 but also activates prosurvival pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the latter requires the CD2-associated adaptor protein (CD2AP) in podocytes. |
| 5 | 19679673 | We found that the C-terminal region of CD2AP interacts directly with the cytoplasmic tail of the TGF-beta receptor type I (TbetaRI) in a kinase-dependent manner and that the interaction between the TbetaRI and the p85 subunit of PI3K requires CD2AP. |
| 6 | 21186102 | It has been recently shown that nephrin once phosphorilated associates with PI3K and stimulates the Akt dependent signaling. |
| 7 | 20054520 | In addition, LY294002, a PI3-K inhibitor, could prevent the quantitative and distributional changes of ZO-1 and RAGE and the increased permeability induced by HG and AGE. |
| 8 | 21215189 | And then, the effects of P38MAPK, PI-3K and ERK1/2 pathway inhibitors (SB203580, LY294002, U0126) and DMSO on CD59 and Crry expression were respectively detected by flow cytometry. |