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Gene Information
Gene symbol: PRKAA1
Gene name: protein kinase, AMP-activated, alpha 1 catalytic subunit
HGNC ID: 9376
Synonyms: AMPKa1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | ADIPOR1 | 1 hits |
| 3 | ALB | 1 hits |
| 4 | ATIC | 1 hits |
| 5 | NOX4 | 1 hits |
| 6 | NOX5 | 1 hits |
| 7 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18941912 | Adiponectin receptor ADIPOR1 activates the intracellular second messenger AMP-activated protein kinase (AMPK) that participates in the control of the oxidative stress and apoptosis. |
| 2 | 18941912 | ADIPOR1 and catalytic AMPK sub-units alpha1 and alpha2 were revealed in normal rat glomeruli and incubation of freshly isolated rat glomeruli with either adiponectin or AICAR led to the activation by phosphorylation of catalytic AMPK. |
| 3 | 18941912 | It is concluded that glomerular cells express a functional adiponectin receptor ADIPOR1 which, through activation of AMPK, may play important roles in the control of oxidative stress and cell survival within the glomerulus. |
| 4 | 20861022 | Here, we show that HG inactivates AMP-activated protein kinase (AMPK), up-regulates Nox4, enhances NADPH oxidase activity, and induces podocyte apoptosis. |
| 5 | 20861022 | Activation of AMPK blocked HG-induced expression of Nox4, NADPH oxidase activity, and apoptosis. |
| 6 | 20861022 | Inactivation of AMPK by HG up-regulated the expression and phosphorylation of p53, and p53 acted downstream of Nox4. |
| 7 | 20861022 | Glomeruli isolated from these mice showed decreased phosphorylation of AMPK and enhanced expression of Nox4 and p53. |
| 8 | 20861022 | Pharmacologic activation of AMPK by 5-aminoimidazole-4-carboxamide-1-riboside in OVE26 mice attenuated Nox4 and p53 expression. |
| 9 | 20861022 | Our results uncover a novel function of AMPK that integrates metabolic input to Nox4 and provide new insight for activation of p53 to induce podocyte apoptosis. |
| 10 | 20861022 | The data indicate the potential therapeutic utility of AMPK activators to block Nox4 and reactive oxygen species generation and to reduce urinary albumin excretion in type 1 diabetes. |