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Gene Information
Gene symbol: PRKAA2
Gene name: protein kinase, AMP-activated, alpha 2 catalytic subunit
HGNC ID: 9377
Synonyms: AMPK, AMPKa2
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
18431508
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In cultured podocytes, adiponectin administration was associated with increased activity of AMPK, and both adiponectin and AMPK activation reduced podocyte permeability to albumin and podocyte dysfunction, as evidenced by zona occludens-1 translocation to the membrane.
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2 |
18431508
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These effects seemed to be caused by reduction of oxidative stress, as adiponectin and AMPK activation both reduced protein levels of the NADPH oxidase Nox4 in podocytes.
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3 |
18431508
|
Ad(-/-) mice treated with adiponectin exhibited normalization of albuminuria, improvement of podocyte foot process effacement, increased glomerular AMPK activation, and reduced urinary and glomerular markers of oxidant stress.
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