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Gene Information
Gene symbol: PTGS2
Gene name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
HGNC ID: 9605
Synonyms: COX2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATP6AP2 | 1 hits |
| 2 | CASP3 | 1 hits |
| 3 | COX8A | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | MAPK14 | 1 hits |
| 6 | MAPK8 | 1 hits |
| 7 | NOS1 | 1 hits |
| 8 | PTGER4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12683421 | Conversely, nitric oxide (NO) generated by neuronal nitric oxide synthase (nNOS) is a positive modulator of COX-2 expression. |
| 2 | 12683421 | Decreased extracellular chloride increases COX-2 expression in cultured cTALH, an effect mediated by increased p38 MAP kinase activity and, in vivo, a sodium-deficient diet increases expression of activated p38 in MD/cTALH. |
| 3 | 21073732 | Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro. |
| 4 | 14665434 | The stretch-induced effects on COX-2/EP4 expression and EP4-induced cAMP production were attributable to p38 MAP kinase, as blockade of this pathway, but not of ERK or JNK, abrogated the response. |
| 5 | 21737546 | In cultured podocytes overexpressing COX-2, high glucose induced cell injury and increased both expression of the pro(renin) receptor and activation of the renin-angiotensin system. |
| 6 | 21737546 | In vivo, podocyte pro(renin) receptor expression increased in diabetic COX-2-transgenic mice, and treatment with a COX-2 inhibitor abrogated the upregulation of (pro)renin receptor and reduced albuminuria, foot-process effacement, and mesangial matrix expansion. |
| 7 | 21737546 | In summary, these results demonstrate that increased expression of podocyte COX-2 predisposes to diabetic glomerular injury and that the (pro)renin receptor may be one mediator for this increased susceptibility to injury. |
| 8 | 21613416 | Using cultured podocytes, we analyzed 1) the roles of MK-2 and p38 MAPK in puromycin aminonucleoside (PAN)-induced podocyte injury; 2) the ability of specific MK-2 and p38 MAPK inhibitors to protect podocytes against injury; 3) the role of serum albumin, known to induce podocyte injury, in activating p38 MAPK/MK-2 signaling; and 4) the role of p38 MAPK/MK-2 signaling in the expression of Cox-2, an enzyme associated with podocyte injury. |