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Gene Information
Gene symbol: RAC1
Gene name: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
HGNC ID: 9801
Synonyms: TC-25, p21-Rac1, Rac-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTN4 | 1 hits |
| 2 | AGT | 1 hits |
| 3 | AGTR1 | 1 hits |
| 4 | ARHGAP24 | 1 hits |
| 5 | CAPZA1 | 1 hits |
| 6 | CD2AP | 1 hits |
| 7 | NRP1 | 1 hits |
| 8 | PARVA | 1 hits |
| 9 | PLAUR | 1 hits |
| 10 | TRPC5 | 1 hits |
| 11 | TRPC6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16314921 | While PARVA inhibits the activities of Rac1 and testicular kinase 1 and cell spreading, PARVB binds alphaPIX and alpha-actinin, and can promote cell spreading. |
| 2 | 18084301 | Mechanistically, uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1. |
| 3 | 18773185 | The free radical scavenger DMTU eliminated Ang II-induced cell migration, ERM protein phosphorylation and cortical F-actin remodeling, indicating that ROS mediates the influence of Rac-1 on podocyte AT1R signaling. |
| 4 | 18773185 | Signaling inhibitor assay of Ang II-treated podocytes reveals that Rac-1, RhoA, and F-actin reorganization were involved in expressional regulation of alpha actinin-4 in AT1R signaling. |
| 5 | 20404345 | We found that CD2AP specifically interacts with the C-terminal domain of Rac1 but not with that of other Rho family members. |
| 6 | 20404345 | CD2AP co-localizes with Rac1 to membrane ruffles, and small interfering RNA-based experiments showed that CD2AP links Rac1 to CAPZ and cortactin. |
| 7 | 20404345 | Finally, expression of constitutive active Rac1 recruits CD2AP to cell-cell contacts in epithelial cells, where we found CD2AP to participate in the control of the epithelial barrier function. |
| 8 | 20978238 | We show that TRPC5 is in a molecular complex with Rac1, whereas TRPC6 is in a molecular complex with RhoA. |
| 9 | 20978238 | TRPC5-mediated Ca(2+) influx induces Rac1 activation, thereby promoting cell migration, whereas TRPC6-mediated Ca(2+) influx increases RhoA activity, thereby inhibiting cell migration. |
| 10 | 21734098 | Analysis of RhoA family GTPase activity demonstrated that treatment with AGE-BSA or NRP1 depletion inhibited as well the activation of the Rac-1 and Cdc42 but did not affect RhoA activity. |
| 11 | 21911940 | Thus, Arhgap24 contributes to the careful balancing of RhoA and Rac1 signaling in podocytes, the disruption of which may lead to kidney disease. |