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Gene Information
Gene symbol: SREBF2
Gene name: sterol regulatory element binding transcription factor 2
HGNC ID: 11290
Synonyms: SREBP2, bHLHd2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADFP | 1 hits |
| 2 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21209008 | Diet-induced obesity (DIO) and insulin resistance in mice are associated with proteinuria, renal mesangial expansion, accumulation of extracellular matrix proteins, and activation of oxidative stress, proinflammatory cytokines, profibrotic growth factors, and the sterol regulatory element binding proteins, SREBP-1 and SREBP-2, that mediate increases in fatty acid and cholesterol synthesis. |
| 2 | 21209008 | An additional novel finding of our study is that activation of VDR results in decreased accumulation of neutral lipids (triglycerides and cholesterol) and expression of adipophilin in the kidney by decreasing SREBP-1 and SREBP-2 expression and target enzymes that mediate fatty acid and cholesterol synthesis and increasing expression of the farnesoid X receptor. |