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Gene Information
Gene symbol: TGFA
Gene name: transforming growth factor, alpha
HGNC ID: 11765
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAM17 | 1 hits |
| 2 | ALB | 1 hits |
| 3 | CD80 | 1 hits |
| 4 | EGFR | 1 hits |
| 5 | LIMS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21052729 | We further hypothesize that under normal circumstances, CD80 expression is only transiently expressed and proteinuria is minimal due to rapid autoregulatory response by circulating T regulatory cells or by the podocyte itself, probably due to the expression of factors [cytotoxic T-lymphocyte-associated (CTLA)-4, interleukin (IL)-10, and possibly transforming growth factor (TGF)-?] that downregulate the podocyte CD80 response. |
| 2 | 17018845 | Glomerular cells in culture respond to albumin containing Amadori glucose adducts (the principal serum glycated protein), with activation of protein kinase C-beta(1), increased expression of transforming growth factor (TGF)-beta1, the TGF-beta type II signaling receptor, and the extracellular matrix proteins alpha(1)(IV) collagen and fibronectin and with decreased production of the podocyte protein nephrin. |
| 3 | 18480182 | Treatment of podocytes with transforming growth factor (TGF)-beta1 elevated the level of PINCH-2, resulting in increased association of PINCH-2 with ILK and alpha-parvin and concomitant displacement of PINCH-1 from the PIP complex. |
| 4 | 19535569 | A disintegrin and metalloproteinase (ADAM)17 sheds growth factors from the cell membrane, including epidermal growth factor receptor (EGFR) ligand transforming growth factor (TGF)-alpha. |
| 5 | 19535569 | In renal fibrosis, ADAM17 colocalized with TGF-alpha. |
| 6 | 19535569 | Moreover, in cultured human podocytes and proximal tubular cells, pharmacological ADAM17 inhibition reduced constitutive TGF-alpha shedding by 78% (P < 0.005) and 100% (P < 0.05), respectively, and phorbol ester-induced TGF-alpha shedding by 84% (P < 0.005) and 92% (P = 0.005), respectively. |