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Gene Information
Gene symbol: USF1
Gene name: upstream transcription factor 1
HGNC ID: 12593
Synonyms: UEF, MLTFI, bHLHb11
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CREB1 | 1 hits |
| 2 | DUSP1 | 1 hits |
| 3 | MAPK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18625721 | Here we show that atRA, through cAMP and PKA, triggers a feed-forward loop involving CREB and USF1 to induce biphasic stimulation of MKP1. atRA stimulated CREB and USF1 binding to the MKP1 gene promoter, as shown by gel shifting and chromatin immunoprecipitation assays. |
| 2 | 18625721 | CREB directly mediated the early phase of atRA-induced MKP1 stimulation; whereas the later phase was mediated by CREB indirectly through induction of USF1. |
| 3 | 18625721 | Consistent with these findings, the biological effects of atRA on podocytes were inhibited by silencing either MKP1, CREB, or USF1 with small interfering RNA. atRA also induced CREB phosphorylation and MKP1 expression and reduced MAPK1,2 phosphorylation in kidneys of HIV type 1-infected transgenic mice. |
| 4 | 18625721 | The mechanism involves a feed-forward loop where activation of one transcription factor (TF) (CREB) leads to induction of a second TF (USF1). |