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Gene Information

Gene symbol: AKT1

Gene name: v-akt murine thymoma viral oncogene homolog 1

HGNC ID: 391

Synonyms: RAC, PKB, PRKBA, AKT

Related Genes

#	Gene Symbol	Number of hits
1	BCL2L11	1 hits
2	CD2	1 hits
3	CD2AP	1 hits
4	IGF1	1 hits
5	INS	1 hits
6	INSR	1 hits
7	IRS1	1 hits
8	NAMPT	1 hits
9	NOX5	1 hits
10	NPHS1	1 hits
11	PIK3CA	1 hits
12	PIK3CG	1 hits
13	PIK3R1	1 hits
14	PRDX2	1 hits
15	SLC2A4	1 hits
16	STN	1 hits
17	VEGFA	1 hits
18	VEGFC	1 hits

Related Sentences

#	PMID	Sentence
1	12832477	We demonstrate that both nephrin and CD2AP interact with the p85 regulatory subunit of phosphoinositide 3-OH kinase (PI3K) in vivo, recruit PI3K to the plasma membrane, and, together with podocin, stimulate PI3K-dependent AKT signaling in podocytes.
2	15780083	IGF-1 stimulation resulted in the formation of the insulin receptor substrate (IRS)-1-p85 complex, an increase in PI3 kinase activity, and activation of protein kinase B (AKT/PKB) and the bcl-2 family member bad.
3	15843472	Moreover, three different statins, mevastatin, pravastatin, and simvastatin, inhibited in a dose-dependent manner apoptosis and loss of nephrin induced by oxLDL by stimulating Akt activity.
4	18172055	Angiotensin II-dependent increases in podocyte NADPH oxidase activity and subunit expression (NOX2, NOX4, Rac, and p22(phox)) and reactive oxygen species generation were decreased after in vitro statin treatment.
5	18249526	Additional studies revealed that SEMA3A effects on ureteric bud branching involve downregulation of glial cell-line derived neurotrophic factor (GDNF) signaling, competition with vascular endothelial growth factor A (VEGF-A) and decreased activity of Akt survival pathways.
6	19261739	Low-dose spironolactone treatment reduced albuminuria and tissue RAAS activity and improved podocyte structural and protein integrity with improvements in IRS-1/Akt phosphorylation.
7	19679673	TGF-beta promotes proapoptotic signaling mediated by Smad3 but also activates prosurvival pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the latter requires the CD2-associated adaptor protein (CD2AP) in podocytes.
8	19556298	At the protein level, phosphorylation of the insulin receptor, IRS1 and PKB was reduced and there was impaired translocation of GLUT4 to the cell surface.
9	20375985	Furthermore, visfatin induced tyrosine phosphorylation of the insulin receptor, activated downstream insulin signaling pathways such as Erk-1, Akt, and p38 MAPK, and markedly increased the levels of TGFbeta1, PAI-1, type I collagen, and MCP-1 in both renal cells.
10	20654688	Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis.
11	21186102	It has been recently shown that nephrin once phosphorilated associates with PI3K and stimulates the Akt dependent signaling.
12	16525158	VEGF-C was also shown to induce a 0.5+/-0.13-fold reduction in levels of MAPK phosphorylation compared with VEGF-A and VEGF-A-Mab treatment (P<0.05, ANOVA, n=4), yet had no effect on Akt phosphorylation.
13	21660954	High glucose treatment also abolished the stimulatory effects of insulin on BK(Ca) current density, although insulin continued to increase phosphorylation of Erk and Akt under those conditions.
14	17667983	Exposure to AGE-BSA was associated with Akt dephosphorylation and FOXO4 transcriptional activation leading to an increase in the expression of an effector protein of apoptosis, Bim. siRNA for FOXO4 abolished AGE-BSA-induced apoptosis of podocytes.
15	21814176	Downregulation of peroxiredoxin 2 in podocytes resulted in increased reactive oxygen species release, protein overoxidation, and inhibition of the Akt pathway.